Manchester United boss Ole Gunnar Solskjaer has decided to hand a start to expensive summer signing Jadon Sancho.
The United boss also decided to drop Fred for this game, with Cristiano Ronaldo and Marcus Rashford starting upfront.
See the full team sheet below
Watford starting XI: Foster, Femenia, Nkoulou, Cathcart, Masina, Cleverley, Sissoko, Louza, Sarr, Dennis, King.
Subs: Bachmann, Ngakia, Rose, Ekong, Gosling, Tufan, Pedro, Fletcher, Hernandez.
Manchester United starting XI: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, McTominay, Matic, Sancho, Fernandes, Rashford, Ronaldo.
Subs: Heaton, Telles, Bailly, Dalot, Fred, van de Beek, Mata, Lingard, Martial.