Manchester United make four changes to the starting line-up from their last game, a humiliating 4-0 loss at Brighton on 7 May.
Edinson Cavani and Hannibal Mejbri both start, with Harry Maguire and Fred also coming in.
Cristiano Ronaldo is not in the squad, with Raphael Varane, Nemanja Matic and Juan Mata also dropping out.
Man Utd XI: De Gea, Dalot, Lindelof, Maguire, Telles, McTominay, Fred, Elanga, Mejbri, Fernandes, Cavani.
Crystal Palace make five changes to the side that capitulated at Everton on Thursday.
Palace XI: Guaita, Clyne, Andersen, Ward, Mitchell, Gallagher, Hughes, Schlupp, Rak-Sakyi, Zaha, Edouard.