Manchester United boss Erik ten Hag has made four changes to the team that defeated Crystal Palace in midweek.
Victor Lindelof, Bruno Fernandes, Marcus Rashford and Rasmus Hojlund all come in for this fixture.
Summer signing Sofyan Amrabat is also set to start in the unfamiliar left back role again.
Man Utd starting XI: Onana, Dalot, Lindelof, Varane, Amrabat, Mount, Casemiro, Pellistri, Bruno Fernandes, Rashford, Hojlund.
Subs: Bayindir, Maguire, Martial, Eriksen, Garnacho, van de Beek, Evans, McTominay, Mejbri.
Crystal Palace starting XI: Johnstone, Ward, Andersen, Guehi, Mitchell, Doucoure, Hughes, Ayew, Schlupp, Eze, Mateta.
Subs: Holding, Clyne, Ebiowei, Richards, Matthews, Riedewald, Rak-Sakyi, Ola-Adebomi, Ozoh.