Manchester United midfielder Casemiro has been ruled out of the club’s Premier League clash with Sheffield United, due to a minor issue which he suffered on international duty.

The 31-year-old was substituted during Brazil’s 1-1 draw with Venezuela last week due to an ankle problem, but he was able to play on Tuesday night against Uruguay, playing the full 90 minutes of the contest.

Despite hopes that he’ll be available to face the Blades this weekend, the club have instead confirmed his unavailability for the game.

“Casemiro was absent [from Thursday’s training session], having remained in Brazil, on the club’s advice, to recover as swiftly as possible from a small issue picked up while playing for his country,” read a club statement on Thursday.

“He will be unavailable for Saturday’s game with the Blades but is expected back at Carrington early next week to resume training, although he is suspended for the UEFA Champions League encounter with FC Copenhagen at Old Trafford, after being sent off in the defeat to Galatasaray.”

Casemiro’s return for the club could therefore come against Manchester City in the Manchester derby on October 29.

The Brazilian has been a key player for the club this season, scoring four goals and providing one assist in 11 appearances in all competitions.